Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene

✍ Scribed by Dr. Göran Stenman; Anders Eriksson; Lena Claesson-Welsh

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 379 KB
• Volume: 1
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870010208

✦ Synopsis

The gene for the human platelet-derived growth factor (PDGF) A type receptor was assigned to the proximal long arm of chromosome 4 by using in situ hybridization. Of 14 I labeled metaphase cells, 74 had grains over chromosome 4, with a distinct peak at bands q l I-ql2. The presence of the gene on chromosome 4 was also confirmed by hybridization to chromosome specific libraries. This places the PDGFA receptor gene in the same region of chromosome 4 as the KIT oncogene, another member of the PDGFgrowth factor receptor subfamily. The two other members of this gene family, the PDGFB receptor and the colony stimulating factor-I (CSFI) receptor, are closely linked on the distal half of the long arm of chromosome 5.