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Human papillomavirus type 18 DNA in gestational trophoblastic tissues and choriocarcinomas

✍ Scribed by Chia C. Pao; Jyu Jen Hor; Chi-Jung Wu; Yi-Fu Shi; Xing Xm; Shi-Ming Lu

Book ID: 102866254
Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 973 KB
Volume: 63
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910630408

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✦ Synopsis

The objectives of our study were to better understand carcinogenesis of gestational trophoblastic tumors and to investigate the possible presence of human papillomavirus types 16 and 18 DNA sequences in these tumors. Amplification-based DNA methodology was used on I I hydatidiform moles, 5 invasive moles, 8 choriocarcinomas and 9 normal early placental tissues. Human papillomavirus type 16 DNA was not found in any of these tissues. Although human papillomavirus type 18 DNA was also not found in the 9 normal placentas and 5 invasive moles, it was present in 2 of the I I (I 8%) hydatidiform moles and in 4 of the 8 (50%) choriocarcinomas.

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