Human Papillomavirus, Lichen Sclerosus, and Squamous Cell Carcinoma of the Vulva: Detection and Prognostic Significance
β Scribed by Anca C. Ansink; Mark R.L. Krul; Roel A. De Weger; John A.F.W. Kleyne; Helga Pijpers; Harm Van Tinteren; Elly W. De Kraker; Theo J.M. Helmerhorst; A.Peter M. Heintz
- Book ID
- 115616061
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 281 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0090-8258
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An 83-year-old woman presented with a vulval mass. Radical vulvectomy was performed and histology showed a unique mixed picture of spindle, pseudoglandular and classical squamous cell carcinoma arising in vulval lichen sclerosus.
## Abstract ## Objectives/Hypothesis: The human papillomavirus (HPV) has been identified as a causative factor in 20% to 25% of all head and neck squamous cell carcinomas (HNSCC). Ongoing research suggests that the presence of HPV DNA in HNSCC predicts a positive prognosis with respect to diseaseβ