Human Papillomavirus Infection and the Multistage Carcinogenesis of Cervical Cancer
β Scribed by Schiffman, M.; Wentzensen, N.
- Book ID
- 121361398
- Publisher
- American Association for Cancer Research
- Year
- 2013
- Tongue
- English
- Weight
- 444 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1055-9965
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π SIMILAR VOLUMES
## Abstract We consider the implications of multistage carcinogenesis for the incidence of cancer in human populations. When clonal expansion of partially altered cells is properly accounted for, we find it unnecessary to invoke genomic instability as an early event in malignant transformation. Env
HPV types 16 and 18 have been categorized as human carcinogens based on their strong associations with cervical cancer in previous case-control studies. Recent IARC studies in the Philippines, Thailand and Morocco show strong associations between invasive cervical cancer and less common HPV types, i