Human papillomavirus E6 protein from both cervical and cutaneous types inhibit p53-dependent and p53-independent apoptosis
β Scribed by Jackson, S.; Leigh, I.M.; Storey, A.
- Book ID
- 119562118
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 204 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0923-1811
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## Abstract Persistent infection with oncogenic human papillomaviruses (HPVs) is the most important factor in the induction of uterine cervical cancer, a leading cause of cancer mortality in women worldwide. Upon cell transformation, continual expression of the viral oncogenes is required to mainta
We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs