## BACKGROUND. Human papillomavirus (HPV) infection represents the most important risk factor for cervical carcinoma. Levels of expression of E6 and E7 transforming oncoproteins of high risk HPV genotypes (i.e., HPV-16 and HPV-18) have been linked specifically to the mitotic activity of cervical c
Human papillomavirus 16E6 oncogene mutation in cervical cancer
β Scribed by Feng Sun; Xiao-qin Ha; Tong-de Lv; Chuan-ping Xing; Bin Liu; Xiao-zhe Cao
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2009
- Tongue
- English
- Weight
- 488 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1000-9604
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Human papillomavirus (HPV) type 16 DNA is frequent in invasive cervical cancers. Among 43 patients with invasive cervical cancer, HPV-16-positive tumors spread to the parametrial and pelvic lymph nodes significantly more often than did HPV-16-negative tumors ( P < 0.05). Demonstration of HPV-16 DNA
High rates of cervical cancer have been reported from parts of China and this may reflect a predominance of cervical infection with particularly aggressive human papillomavirus (HPV) variants. This PCR-based investigation of cervical tumours from Sichuan province in central China demonstrated an HPV