## BACKGROUND. Human papillomavirus (HPV) infection represents the most important risk factor for cervical carcinoma. Levels of expression of E6 and E7 transforming oncoproteins of high risk HPV genotypes (i.e., HPV-16 and HPV-18) have been linked specifically to the mitotic activity of cervical c
Evidence of Diversifying Selection in Human Papillomavirus Type 16 E6 But Not E7 Oncogenes
✍ Scribed by Victor R. DeFilippis; Francisco J. Ayala; Luis P. Villarreal
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 153 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2844
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Human papillomavirus (HPV) DNA sequences are found in most carcinomas originating from the uterine cervix. HPV E6 and E7 oncogenes have been shown to cooperate with ras oncogenes to fully transform human epithelial cells. We investigated the effect of the Ha-ras oncogene on the transcriptional activ
## Abstract Human papillomavirus (HPV) infection is associated with cervical cancer. The E2 and E1 papillomavirus proteins are expressed at the early stage of infection and regulate DNA replication. The E2 protein activates and represses transcription from different HPVs promoters. At some stage wh