✦ LIBER ✦

Human ?-opioid receptor gene and susceptibility to heroin and alcohol dependence

✍ Scribed by Franke, Petra; N�then, Markus M.; Wang, Tao; Neidt, Helge; Knapp, Michael; Lichtermann, Dirk; Weiffenbach, Olaf; Mayer, Peter; H�llt, Volker; Propping, Peter; Maier, Wolfgang

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 10 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19991015)88:5<462::aid-ajmg4>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

In the present study, we tested the hypothesis that addictive behavior may be influenced by genetic variation in the human ␦-opioid receptor gene. We investigated the contribution of a silent T to C change in the coding region to the development of heroin and alcohol dependence using large casecontrol and family-based association samples. Presence of the C allele was previously reported to significantly increase the risk for heroin dependence. In the present study, however, we did not find statistically significant differences between patients and controls nor did we find preferential transmission of the C allele from parents to affected offspring. Our results, therefore, do not support an association between genetic variation of the ␦-opioid receptor and addictive behavior in man.

📜 SIMILAR VOLUMES

Human chromosomes 11p15 and 4p12 and alc

Human chromosomes 11p15 and 4p12 and alcohol dependence: Possible association with theGABRB1 gene

✍ Parsian, Abbas; Zhang, Zhen Hua 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 21 KB 👁 1 views

To determine the role of genes in the chromosomal regions 11p15 and 4p12 in the development of alcohol dependence, a sample of alcoholics (n = 133) and normal controls (n = 89) were screened using polymorphisms in the dopamine D4 receptor (DRD4), tyrosine hydroxylase (TH), and GABA receptor ␤1 (GABR

Human dopamine transporter gene polymorp

Human dopamine transporter gene polymorphism (VNTR) and alcoholism

✍ Parsian, Abbas; Zhang, Zhen Hua 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 8 KB 👁 2 views

The dopamine transporter (DAT1) is responsible for taking released dopamine back up into presynaptic terminals and terminating dopaminergic activity. It has been shown that cocaine binds to the dopamine transporter and blocks dopamine reuptake in a fashion that correlates with cocaine reward and rei

Association of a functional ?-opioid rec

Association of a functional ?-opioid receptor allele (+118A) with alcohol dependency

✍ Town, Terrence; Abdullah, Laila; Crawford, Fiona; Schinka, John; Ordorica, Patri 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 13 KB 👁 1 views

Genetic association studies have implicated the TaqI A1 allele of the human dopamine D2 receptor gene (DRD2) as a riskdetermining factor for alcohol dependency. However, as alcoholism is a disease of polygenic inheritance, the percentage of overall disease variance explained by the TaqI A1 allele is

Linkage studies of D2 and D4 receptor ge

Linkage studies of D2 and D4 receptor genes and alcoholism

✍ Hill, Shirley Y.; Zezza, Nick; Wipprecht, Ginger; Xu, Jie; Neiswanger, Kathy 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 33 KB 👁 2 views

The purpose of the present study was to evaluate two polymorphisms near the D2 receptor gene (TaqI A RFLP and C microsatellite) and a VNTR for D4. A nonparametric linkage (NPL) technique, SIBPAL, was used to test for the presence or absence of linkage in 54 multiplex alcoholic families. These famili

Mutation screening of the dopamine D1 re

Mutation screening of the dopamine D1 receptor gene in tourette's syndrome and alcohol dependent patients

✍ Thompson, Miles; Comings, David E.; Feder, Leanne; George, Susan R.; O'Dowd, Bri 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 15 KB 👁 2 views

We report a single stranded conformational polymorphism (SSCP) analysis of the coding region of the dopamine D1 receptor (DRD1) in Tourette's syndrome (n = 50) and control (n = 50) subjects. Tourette's syndrome populations with comorbidity for attention deficit-hyperactivity disorder (AD-HD) (n = 35

Heroin and other opioids: poppies' perilous children

✍ E. J. Sanna 📂 Fiction 📅 2013 🏛 National Highlights Inc;Mason Crest Publishers 🌐 English ⚖ 1 MB 👁 1 views

Heroin, opium, morphine, and codeine--the natural opioids. In Heroin and Other Opioids: Poppies' Perilous Children, you'll learn about these substances as well as newer derivatives, all of which can impact lives in serious and negative ways. Take a trip through the history of opium production and us