Human Monoclonal Antibodies to Human Cytomegalovirus
โ Scribed by Foung, S. K. H.; Perkins, S.; Bradshaw, P.; Rowe, J.; Rabin, L. B.; Reyes, G. R.; Lennette, E. T.
- Book ID
- 124050901
- Publisher
- University of Chicago Press
- Year
- 1989
- Tongue
- English
- Weight
- 689 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0022-1899
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Two murine monoclonal antibodies (C6D1 and D2B1) were found to react with a set of cytomegalovirus (CMV)-infected cell polypeptides, which comprise a major target of the human immune response to CMV. C6D1 reacted with proteins of 50 kilodaltons (KD) and 40KD molecular weight; D2B1 reacted with these
Of nine mouse monoclonal antibodies (MAbs) directed against the lower matrix protein (pp65; ppUL83) of human cytomegalovirus (HCMV), all immunoprecipitated the 65-kDa protein. Only five were reactive by Western blotting, however, and four of these mapped to linear antigenic epitopes located between
A human monoclonal antibody to cytomegalovirus (CMV) was produced by transforming peripheral blood mononuclear cells of a patient with recent CMV infection. It is directed against a late antigen located in the nucleus of CMV infected fibroblasts at 24-72 hours postinfection and immuneprecipitates 65