✦ LIBER ✦
Production and characterisation of a human monoclonal antibody to cytomegalovirus and its use in an early nuclear fluorescence assay
✍ Scribed by S. Sutherland; D. H. Crawford; S. A. Wilson; B. Morgan; T. Azim; E. R. Huehns
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 674 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
A human monoclonal antibody to cytomegalovirus (CMV) was produced by transforming peripheral blood mononuclear cells of a patient with recent CMV infection. It is directed against a late antigen located in the nucleus of CMV infected fibroblasts at 24-72 hours postinfection and immuneprecipitates 65K and 48K proteins from 35S-labelled CMV infected cells. Results of its use in an early nuclear fluorescence assay for rapid diagnosis are presented.