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Human malignant melanoma antigenic properties of phenol water extracts

✍ Scribed by L. Suter; H. Tilkorn; P. M. Kövary

Book ID
104766700
Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
646 KB
Volume
264
Category
Article
ISSN
0340-3696

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✦ Synopsis

Tumor-associated antigens were demonstrated in phenol water extracts of human malignant melanoma by migration tests with leukocytes from melanoma patients and controls: in 25 out of 60 melanoma patients weak reactivity was observed, usually stimulation of leukocyte migration, while leukocytes from 37 controls were negative in 100 tests. The frequency of positive reactions did not differ significantly in patients with and without metastases. Humoral antibodies against antigens of phenol water extracts were not detectable in melanoma patients. Rabbits did not produce antibodies against tumor typical substances after immunization with phenol water extracts.

Tumor associated antigens of phenol water extracts are presumably not targets of antitumor immune reactions that can influence the clinical course.

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