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Human leukemic “null” cell line (NALL-1)

✍ Scribed by Shunkichi Hiraki; Isao Miyoshi; Ichiro Kubonishi; Yuzo Matsuda; Takashi Nakayama; Hirofumi Kishimoto; Hiroshi Masuji

Book ID
102664682
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
963 KB
Volume
40
Category
Article
ISSN
0008-543X

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✦ Synopsis

A human lymphoblast cell line, NALL-1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). NALL-1 cells had neither properties of T and B cells nor Epstein-Barr virus (EBV). Many characteristics of the NALL-1 line were distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. NALL-1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional features. The NALL-1 line is the first human leukemic "null" cell line derived from ALL. The significance of this cell line is disscussed.

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