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Human imaging of phosphorus in cortical and trabecular bone in vivo

✍ Scribed by Matthew D. Robson; Peter D. Gatehouse; Graeme M. Bydder; Stefan Neubauer

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
253 KB
Volume
51
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Phosphorus was imaged in vivo in human cortical and trabecular bone and the T~1~ and T were measured. An ultrashort TE (UTE) pulse sequence (TE = 70 μm) was used with half pulse excitation and radial mapping of k‐space from the center out. T was measured using multiple echo times and T~1~ was measured both by saturation recovery and by a method using different RF pulse amplitudes. Seven normal subjects (32–85 years) were examined. Phosphorus was imaged, with a true in‐plane resolution of 2.9 × 2.9 mm and a signal‐to‐noise ratio (SNR) of 19:1, in both cortical and trabecular bone. The mean T value was 207 ± 12 μs, and the mean T~1~ value was 8.6 ± 3.0 sec. Images and measurements were obtained in realistic times on a clinical MR system. This may provide a new approach to characterizing disease of bone. Magn Reson Med 51:888–892, 2004. © 2004 Wiley‐Liss, Inc.

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