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Human IgG aggregates induce selective stimulation of IgM rheumatoid factor synthesis by rheumatoid blood mononuclear cells

✍ Scribed by Xue Lian Tao; Nancy Olsen; Morris Ziff; Hugo E. Jasin


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
559 KB
Volume
27
Category
Article
ISSN
0004-3591

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✍ Edward J. Pisko; Robert A. Turner; Susan L. Foster 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 915 KB

## Abstract Normal human peripheral blood mononuclear leukocytes were induced to become cells that secrete rheumatoid factor after culture with aggregated IgG, but not monomeric IgG. A plaque‐forming cell assay was used to detect cells that secrete antibodies to IgG. Anti‐haptenated–sheep red cell