Human Glial Cell-Line-Derived Neurotrophic Factor: A Structure–Function Analysis
✍ Scribed by Zhe-Yu Chen; Zhi-Yong He; Cheng He; Chang-Lin Lu; Xiang-Fu Wu
- Book ID
- 115585288
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 154 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0006-291X
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Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg
Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures includi