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Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

โœ Scribed by Lu, Hua; Zawel, Leigh; Fisher, Laurent; Egly, Jean-Marc; Reinberg, Danny


Book ID
109781469
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
713 KB
Volume
358
Category
Article
ISSN
0028-0836

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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom