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Human Embryonic Stem Cells Fail to Activate CHK1 and Commit to Apoptosis in Response to DNA Replication Stress

✍ Scribed by Joëlle A. Desmarais; Michele J. Hoffmann; Gregg Bingham; Mary E. Gagou; Mark Meuth; Peter W. Andrews

Book ID
112211924
Publisher
AlphaMed Press
Year
2012
Tongue
English
Weight
749 KB
Volume
30
Category
Article
ISSN
1066-5099

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## Abstract An important physiological function of vascular endothelial cells is to detect and respond to physical stimuli. While many efforts have been made to derive endothelial cells from human embryonic stem cells (hESCs), the ability of these derivatives to respond to mechanical forces has yet