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Human DNA polymerase iota protects cells against oxidative stress

✍ Scribed by Petta, Tirzah Braz; Nakajima, Satoshi; Zlatanou, Anastasia; Despras, Emmanuelle; Couve-Privat, Sophie; Ishchenko, Alexander; Sarasin, Alain; Yasui, Akira; Kannouche, Patricia

Book ID
109849601
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
840 KB
Volume
27
Category
Article
ISSN
0261-4189

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## Abstract The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP^+^ to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SH‐SY5Y cells overexpressing IDPm (S1). S1 cells showed higher NADPH and GSH level