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Autotaxin protects microglial cells against oxidative stress

✍ Scribed by Rana Awada; Philippe Rondeau; Sandra Grès; Jean Sébastien Saulnier-Blache; Christian Lefebvre d'Hellencourt; Emmanuel Bourdon


Book ID
111876036
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
946 KB
Volume
52
Category
Article
ISSN
0891-5849

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## Abstract The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP^+^ to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SH‐SY5Y cells overexpressing IDPm (S1). S1 cells showed higher NADPH and GSH level