𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Human cytomegalovirus terminase as a target for antiviral chemotherapy

✍ Scribed by Elke Bogner

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
519 KB
Volume
12
Category
Article
ISSN
1052-9276

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Herpesviral DNA packaging is a complex process involving binding and cleavage of DNA containing the specific DNA‐packaging motifs, pac1 and pac2, and packaging of the resulting unit‒length genomes into preformed procapsids. This process is believed to be mediated by two packaging proteins, the terminase subunits. In the case of human cytomegalovirus the terminase consists of the proteins pUL56 and pUL89. While pUL56 (i) mediates the specific binding to pac sequences on the concatamers, (ii) provides energy for the translocation of the DNA to the procapsids and (iii) associates itself with the capsid for enabling the entry of the DNA into the procapsid, pUL89 is mainly required to effect DNA cleavage. Based on the limited efficacy of the current drugs ganciclovir, cidofovir and foscarnet, new antiviral therapeutics appear to be in demand. Inhibitors targeting pUL56 and/or pUL89 may offer an attractive alternative since mammalian cell DNA replication does not involve cleavage of concatameric DNA. Drugs targeted to terminase‐like proteins should therefore be safe and highly selective. Copyright © 2002 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

HIV integrase as a target for antiviral
HIV integrase as a target for antiviral chemotherapy
✍ Vasu Nair 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 383 KB

## Abstract One of the three key enzymes encoded by the __pol__ gene of HIV is a __M__~r~ 32 000 protein called HIV integrase. This viral enzyme is involved in the integration of HIV DNA into host chromosomal DNA. There appears to be no functional equivalent of the enzyme in human cells. The bioche

Protein–protein interactions as targets
Protein–protein interactions as targets for antiviral chemotherapy
✍ Arianna Loregian; Howard S. Marsden; Giorgio Palù 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

## Abstract Most cellular and viral processes depend on the coordinated formation of protein–protein interactions. With a better understanding of the molecular biology and biochemistry of human viruses it has become possible to screen for and detect inhibitors with activity against specific viral f

Chemotherapy resistant transitional cell
Chemotherapy resistant transitional cell carcinoma as a target for chemoprevention
✍ Christopher J. Logothetis 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB

alpha-Interferon combined with 5-fluorouracil results in significant antitumoral activity in metastatic bladder carcinoma refractory to standard MVAC chemotherapy. As a single agent, alpha-interferon is ineffective for invasive or metastatic disease, but appears to contribute to the increased respon