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Human cytomegalovirus DNA replication: antiviral targets and drugs

✍ Scribed by Beatrice Mercorelli; Elisa Sinigalia; Arianna Loregian; Giorgio Palù

Book ID
104590618
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
362 KB
Volume
18
Category
Article
ISSN
1052-9276

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✦ Synopsis

Abstract

Human cytomegalovirus (HCMV) infection is associated with severe morbidity and mortality in immunocompromised individuals, in particular transplant recipients and AIDS patients, and is the most frequent congenital viral infection in humans. There are currently five drugs approved for HCMV treatment: ganciclovir and its prodrug valganciclovir, foscarnet, cidofovir and fomivirsen. These drugs have provided a major advance in HCMV disease management, but they suffer from poor bioavailability, significant toxicity and limited effectiveness, mainly due to the development of drug resistance. Fortunately, there are several novel and potentially very effective new compounds which are under pre‐clinical and clinical evaluation and may address these limitations. This review focuses on HCMV proteins that are directly or indirectly involved in viral DNA replication and represent already established or potential novel antiviral targets, and describes both currently available drugs and new compounds against such protein targets. Copyright © 2007 John Wiley & Sons, Ltd.

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