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Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma

✍ Scribed by Matsuda, Takao; Sasaki, Masahiro; Kato, Hidenori; Yamada, Hideto; Cohen, Maurice; Barrett, J Carl; Oshimura, Mitsuo; Wake, Norio

Book ID: 110061035
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 256 KB
Volume: 15
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201461

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## Abstract In multiple endocrine neoplasia syndrome Type 2 (MEN2), medullary thyroid carcinoma (MTC) and pheochromocytoma (PC) are associated with hereditary activating germ‐line mutations in the __RET__ proto‐oncogene. Also in a large percentage of sporadic MTCs and PCs, somatic __RET__ mutations