Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT)
โ Scribed by Dong-Lai Qi; Takahito Ohhira; Mitsuo Oshimura; Hiroyuki Kugoh
- Book ID
- 116300550
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 820 KB
- Volume
- 398
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Telomerase, the ribonucleoprotein enzyme that maintains the telomere, is active in human germ and stem cells and in a majority of tumor tissues and immortalized cell lines. In contrast, telomerase activity is not detected in most somatic cells, suggesting that normal human cells contain
Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements an