Human ASH1 expression in prostate cancer with neuroendocrine differentiation
โ Scribed by Rapa, Ida; Ceppi, Paolo; Bollito, Enrico; Rosas, Rosj; Cappia, Susanna; Bacillo, Elisa; Porpiglia, Francesco; Berruti, Alfredo; Papotti, Mauro; Volante, Marco
- Book ID
- 109887659
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 304 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0893-3952
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Neuroendocrine differentiation in prostate cancer has received much attention recently because it has been found to be associated with androgen independence and shortened patient survival in some studies. We have investigated the effect of the cytokines interleukin-1 (IL-1), IL-2, and IL-6 on the ex
## Background: In the human prostate cancer cell line lncap, interleukin (il)-6 has been shown to regulate both growth and neuroendocrine (ne) differentiation. we recently observed that il-6 mediated growth arrest in lncap by activating stat 3. since differentiation and growth arrest are often asso