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Human Arthritic Synovial Fluid Influences Proteoglycan Biosynthesis and Degradation in Organ Culture of Bovine Nasal Cartilage

✍ Scribed by Tore Saxne; Dick Heinegård; Frank A. Wollheim


Book ID
114179120
Publisher
Elsevier
Year
1988
Weight
798 KB
Volume
8
Category
Article
ISSN
0174-173X

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti