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Human and monoclonal antibodies to hepatitis B core antigen recognise a single immunodominant epitope

✍ Scribed by R. Bridget Ferns; Richard S. Tedder

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 664 KB
Volume: 19
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890190213

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✦ Synopsis

Monoclonal antibodies were raised against hepatitis B core antigen (HBcAg) synthesized in Escherichia coli. They identified a single immunodominant determinant on both liver-derived and E. coli-derived HBcAg. Cross-inhibition studies demonstrated that HBsAg-containing human sera which contained antibodies to HBcAg (anti-HBc) together with either hepatitis B e antigen (HBeAg) or its antibody (anti-HBe) essentially only recognised the same single determinant as the murine antibodies. The identification of a single dominant HBcAg determinant may be important if future hepatitis B virus vaccines contain HBcAg.

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