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Human Alu element retrotransposition induced by genotoxic stress

✍ Scribed by Hagan, Christy R; Sheffield, Rebecca F; Rudin, Charles M

Book ID: 109918787
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 958 KB
Volume: 35
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng1259

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## Abstract E2F1, a member of the E2F family of transcription factors, plays a critical role in controlling both cell cycle progression and apoptotic cell death in response to DNA damage and oncogene activation. Following genotoxic stresses, E2F1 protein is stabilized by phosphorylation and acetyla