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HTLV-I-positive and HTLV-I-negative peripheral T-cell lymphomas in Taiwan Chinese

✍ Scribed by Lee-Yung Shih; Tseng-Long Kuo; Po Dunn; Shiumn-Jen Liaw

Book ID
102864216
Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
758 KB
Volume
50
Category
Article
ISSN
0020-7136

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✦ Synopsis

The clinico-pathologic features of 107 adult Chinese patients with peripheral T-cell lymphoma (excluding primary cutaneous lymphoma) are described and a comparison between HTLV-I+ and HTLV-I-patients is made. There were 27 HTLV-I+ and 80 HTLV-I-patients. The virus-positive and -negative groups both had a male predominance and an identical median age of 48. Most patients in both groups presented with stage-lV disease, B symptoms, lymphadenopathy and hepatosplenomegaly. The HTLV-I+ group had a significantly higher incidence of skin and pulmonary lesions, bone marrow and peripheral blood involvement, hypercalcemia, and elevated LDH level compared to the HTLV-I-group. Sinonasal lesions (I 0), mediastinal mass (5), and GI tract involvement (6) were only seen in the HTLV-I-group. Leukocytosis with the presence of circulating pleomorphic lymphoid cells was characteristic of HTLV-I+ cases, while cytopenia was more frequently present in HTLV-I-cases. All of the 24 HTLV-I+ patients tested were CD4+CD8-; of the 67 HTLV-I-patients tested, 46 were CD4+CD8-, 9 were CD4-CD8+, 5 were CD4-CD8-and 7 were CD4+CD8+. Phenotypic studies revealed significant differences in the expression of CD7 and CD25 between virus-positive and -negative groups. Both groups responded poorly to therapy. The median survival of HTLV-I+ and HTLV-I-patients was 4 months and 13.5 months, respectively. Apart from the presence of more than 3 extranodal lesions, none of the other clinical features or histologic subtypes had prognostic significance in the entire group or either of the subgroups. This series of peripheral T-cell lymphomas in Taiwan indicate that HTLV-I' and HTLV-I-patients had many features in common, but presented several distinct differences.

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