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Chromosomal abnormalities in non-hodgkin lymphoma with peripheral t-cell type: Effect of HTLV-I infection

✍ Scribed by Isao Sanada; Toshinori Ishii; Masao Matsuoka; Etsuko Kumagai; Hiromichi Nishimura; Kazunari Yamaguchi; Kiyoshi Takatsuki

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 945 KB
Volume: 5
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900050302

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✦ Synopsis

Cytogenetic studies were done in lymph node and peripheral leukemic cells from sixteen patients with non-Hodgkin lymphoma with peripheral T-cell type. Ten patients were positive for human T-cell leukemia virus I (HTLV-I) proviral DNA in tumour cells and six were negative. The former group had a higher tendency for leukemic conversion and poorer prognosis than the latter. However, no definite difference on the numerical and structural chromosomal abnormalities between these two groups was found. The most frequent chromosome abnormalities: 14p+, 1% + and No. 6 abnormalities were detected in both groups. These results may indicate that HTLV-I does not play a specific role in chromosome abnormalities of non-Hodgkin lymphoma with peripheral T-cell type.

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