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hTERT mRNA expression correlates with telomerase activity in human breast cancer

✍ Scribed by K.L. Kirkpatrick; G. Clark; M. Ghilchick; R.F. Newbold; K. Mokbel


Book ID
117817977
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
203 KB
Volume
29
Category
Article
ISSN
0748-7983

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Hypermethylation of the human telomerase
✍ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 French βš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome