hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines
✍ Scribed by Gabriele Saretzki; Simone Petersen; Iver Petersen; Konrad Kölble; Thomas von Zglinicki
- Book ID
- 117467052
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 617 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0304-3835
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DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome
## Abstract In a majority of malignant human tumors telomerase activity can be detected, suggesting an immortal phenotype. Expression of the reverse transcriptase subunit, hTERT, in the human telomerase complex is required for telomerase activity. The regulation of hTERT, from gene level to a fully