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Hsp90 as a Target for Drug Development

✍ Scribed by Subhabrata Chaudhury; Timothy R. Welch; Brian S. J. Blagg


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
605 KB
Volume
1
Category
Article
ISSN
1860-7179

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## Abstract The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches are required. One suc