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Hsp90 as a Target for Drug Development

✍ Scribed by Subhabrata Chaudhury; Timothy R. Welch; Brian S. J. Blagg

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches are required. One suc