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HSF1 and Sp1 Regulate FUT4 Gene Expression and Cell Proliferation in Breast Cancer Cells

โœ Scribed by Yang, Xuesong; Wang, Jiao; Liu, Shuiai; Yan, Qiu

Book ID
120985543
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
888 KB
Volume
115
Category
Article
ISSN
0730-2312

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## Abstract Cancers express high levels of fatty acid synthase (FAS) from which they derive fatty acids for membrane biosynthesis to sustain cell proliferation. How cancer cells coordinate __de novo__ lipogenesis and proliferation has not been investigated. Transcription factors Sp1, Sp3 and Sp4 ar