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HPLC of antibiotics. 1. Streptolydigin and related compounds

✍ Scribed by Brodasky, Thomas F.

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 425 KB
Volume: 1
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240010505

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✦ Synopsis

Abstract

Two new acyltetramic acids related to streptolydigin have been isolated from fermentations of Streptomyces lydicus. The principal members of this complex were resolved by TLC on silica gel. However, the methods of detection, permanganate spray or bioautography, were not suitable for both crude fermentation broths and purified extracts. Gas chromatography is unsuitable for the detection of either underivatized or silylated streptolydigins. High performance liquid chromatography (HPLC) particularly on triethylaminoethyl cellulose is rapid and sensitive and is the method of choice for the analysis of both crude and purified samples. Using high performance liquid chromatography, two components were detected in the complex, which are not observed using any of the other chromatographic procedures.

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