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HPLC enantioseparation of β2-homoamino acids using crown ether-based chiral stationary phase

✍ Scribed by Róbert Berkecz; István Ilisz; Aleksandra Misicka; Dagmara Tymecka; Ferenc Fülöp; Hee Jung Choi; Myung Ho Hyun; Antal Péter

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
952 KB
Volume
32
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

RP high‐performance liquid chromatographic methods were developed for the enantioseparation of eleven unusual β^2^‐homoamino acids. The underivatized analytes were separated on a chiral stationary phase containing (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid as chiral selector. The effects of organic (alcoholic) and acidic modifiers, the mobile phase composition and temperature on the separation were investigated. The structures of the substituents in the α‐position of the analytes substantially influenced the retention and resolution. The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.

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