Direct Chiral Resolution of Phenylalkylamines Using a Crown Ether Chiral Stationary Phase

✍ Scribed by Hassan Y. Aboul-Enein; Vince Serignese

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 211 KB
• Volume: 11
• Category: Article
• ISSN: 0269-3879
• DOI: 10.1002/(sici)1099-0801(199701)11:1<7::aid-bmc607>3.0.co;2-f

✦ Synopsis

A direct, isocratic high-performance liquid chromatographic method is described for the enantiomeric resolution of a number of phenylalkylamines, namely, racemic cathinone, amphetamine, norephedrine, and norphenylephrhe, without sample derivatization. The separations were achieved on an S-18-crownd-ether chiral stationary phase known as CR(+). The chromatographic parameters a (separation factor) and R, (resolution factor) lay within a narrow range for all compounds used in this study except for cathinone, which resulted in high a and R, values. The recognition mechanism for this column involves the interaction of the crown structure with a charged primary ammonium ion. The stereochemical structures of the compounds in this study contribute to the results obtained for the chromatographic parameters, especially in cathinone's case. This paper will discuss the recognition mechanism contributing to the high a and R, values obtained for cathinone.