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HPLC determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and biological fluids

โœ Scribed by Vanna Springolo; Germano Coppi

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
499 KB
Volume
7
Category
Article
ISSN
0731-7085

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โœฆ Synopsis

Two HPLC methods for determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and in biological fluid are reported. Both methods show good linearity, precision, accuracy and reproducibility. The serum levels and urinary excretion of tetroxoprim and sulphadiazine in man, after oral administration of two different syrup formulations, are reported. Tetroxoprim embonate, an insoluble salt very useful for obtaining a suspension with good palatability, shows a bioavailability not statistically different from that of tetroxoprim base. Sulphadiazine shows the same bioavailability in the two syrups.

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