Determination of methyldopa in pharmaceutical dosage forms and biological fluids based on oxidation at the tubular carbon electrode

✍ Scribed by James T. Stewart; Hoo C. Lo; William D. Mason

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 243 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630636

✦ Synopsis

A method for the determination of methyldopa in pharmaceutical dosage forms based on electrochemical oxidation at the tubular carbon electrode is presented. The method is highly specific and may be used to analyze methyldopa in the presence of other types of pharmaceuticals. A comparison with two other colorimetric procedures of analysis shows the new method to have fewer manipulative steps with comparable precision and accuracy. In addition, the utility of the method in determining methyldopa in urine, plasma, and whole blood is demonstrated.

Keyphrases Methyldopa-method for determination in pharmaceutical dosage forms, urine, plasma, and whole blood, electrochemical oxidation, tubular carbon electrode, compared to compendial and modified colorimetric procedures Oxidation, electrochemical-use of tubular carbon electrode for determination of methyldopa in pharmaceutical dosage forms, urine, plasma, and whole blood Tubular carbon electrode-determination of methyldopa in pharmaceutical dosage forms and biological fluids

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