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HPLC determination and pharmacokinetics of the new original domestic drug dibufelon®

✍ Scribed by S. N. Kondratenko; A. K. Starodubtsev; G. A. Belyakova

Publisher: Springer
Year: 2009
Tongue: English
Weight: 104 KB
Volume: 43
Category: Article
ISSN: 0091-150X
DOI: 10.1007/s11094-010-0370-4

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## Abstract The pharmacokinetics of recainam, an anti‐arrhythmic drug, were compared in mice, rats, rabbits, dogs, rhesus monkeys, and man, Bioavailability was virtually complete in monkeys and dogs, 67 per cent in man and 51 per cent in rats. Non‐linear kinetics between the oral and i.v. dose in r