A new gas chromatographic/mass spectrometric method in combination with isotope dilution for the determination of thyroxine in serum is described. Special attention was paid to the methylation step of thyroxine, which was investigated using methanolic HCI, dimethylformamide/dimethylacetal and diazom
β¦ LIBER β¦
Developing chromatography-mass spectrometry techniques for quantitative determination of the new original neuroleptic drug dilept
β Scribed by N. V. Arkhipenko; S. A. Appolonova; T. G. Sobolevskii; G. M. Rodchenkov; S. S. Boiko; G. B. Kolyvanov; D. V. Bastrygin; V. P. Zherdev
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 183 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0091-150X
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This work describes real examples of classes of drugs (drug candidates) whose quantitative determination in biological matrices by high performance liquid chromatography with electrospray tandem mass spectrometry (LC/MS/MS) may be hampered by interferences from drug-related biotransformation product