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HPLC and LC-MS studies of hydroxylation of phenylalanine as an assay for hydroxyl radicals generated from Udenfriend’s reagent

✍ Scribed by Min Li; Sarah Carlson; Jeffery A Kinzer; Holly J Perpall


Book ID
116287419
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
219 KB
Volume
312
Category
Article
ISSN
0006-291X

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Aromatic hydroxylation of phenylalanine
✍ Harparkash Kaur; Ingrid Fagerheim; Martin Grootveld; Alain Puppo; Barry Halliwel 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 650 KB

Attack of hydroxyl radical (.OH), generated by a Fenton system at physiological pH, upon L-phenylalanine produces three isomeric tyrosines, o-tyrosine (2-hydroxyphenylalanine), m-tyrosine (3-hydroxyphenylalanine), and p-tyrosine (4-hydroxyphenylalanine). These may be separated by high-performance li