HPLC and GLC determination of residual solvents in busulphan

✍ Scribed by O.I. Kalchenko; V.A. Golub; I.V. Zavatskaja

• Book ID: 103912435
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 302 KB
• Volume: 14
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(95)01617-1

✦ Synopsis

Quantitative methods using HPLC and GLC for the determination of residual pyridine and ethanol in busulphan have been developed. The measurement errors for pyridine and ethanol in busulphan samples (p = 0.95) were found to be 10% and 7%. It was shown that one recrystallization enabled pure busulphan to be prepared.