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HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product

✍ Scribed by Milan Mokrý; Jiří Klimeš; Jana Pechová

Book ID
111491334
Publisher
Versita
Year
2010
Tongue
English
Weight
241 KB
Volume
64
Category
Article
ISSN
0366-6352

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✦ Synopsis

Abstract

The present paper deals with the evaluation of nimesulide, 2-phenoxy-4-nitroaniline, the main hydrolytic degradation product of nimesulide, of methylparaben and propylparaben, and eventually of 4-hydroxybenzoic acid by HPLC with UV detection at 254 nm in syrup as a pharmaceutical formulation. HPLC analysis was employed on the reversed phase C18 with methanol and 0.01 M dibasic ammonium phosphate (ρ r = 60: 40, pH 4.0). Validation was performed using standards and a pharmaceutical preparation containing the compounds described above.

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