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HPLC ANALYSIS OF A NEW NEUROPROTECTIVE AGENT FOR ISCHEMIA-REPERFUSION DAMAGE, A BENZOPYRAN DERIVATIVE, IN PLASMA AND URINE

✍ Scribed by Lee, Mi H.; Kim, Eun Jung; Kim, Sun-Ok; Lee, Dong Ha; Lim, Hong; Yoo, Sung-E.; Lee, Myung Gull


Book ID
127138896
Publisher
Taylor and Francis Group
Year
2002
Tongue
English
Weight
124 KB
Volume
25
Category
Article
ISSN
1082-6076

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## Abstract The dose‐dependent pharmacokinetic parameters of a new neuroprotective agent for ischemia‐reperfusion damage, KR‐31378, were evaluated after intravenous and oral administration, 10, 20, and 50 mg/kg, to rats. After intravenous administration of 50 mg/kg, the dose‐normalized (10 mg/kg) A

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The purpose of this study was to report dose-independent pharmacokinetics of KR-31543, a new neuroprotective agent for ischemia-reperfusion damage, after intravenous (iv) and oral (po) administration and first-pass effects after iv, intraportal, intragastric, and intraduodenal administration in rats