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How Insulin-Like Growth Factor Hormones, IGF1 And IGF2, Engage their Cognate Receptor

✍ Scribed by Vashisth, Harish; Abrams, Cameron F.

Book ID: 122526956
Publisher: Biophysical Society
Year: 2010
Tongue: English
Weight: 30 KB
Volume: 98
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.1320

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## Background and Objectives: We have previously shown that insulin-like growth factor (IGF)-responsive murine sarcomas demonstrate inhibition of local and metastatic disease growth when implanted in an IGF-deficient host animal. In this experiment, we tested whether IGF receptor (IGF-R) and ligan