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How HLA-DM Affects the Peptide Repertoire Bound to HLA-DR Molecules

✍ Scribed by Anne B Vogt; Harald Kropshofer; Günter J Hämmerling


Book ID
117415636
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
580 KB
Volume
54
Category
Article
ISSN
0198-8859

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How HLA-DM edits the MHC class II peptid
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Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro findings with isolated class II proteins and synthetic peptides. Do accessory proteins speed up the loading proc