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How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?

✍ Scribed by Harald Kropshofer; Günter J. Hämmerling; Anne B. Vogt

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 637 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01006-2

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✦ Synopsis

Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro findings with isolated class II proteins and synthetic peptides. Do accessory proteins speed up the loading process in antigen-presenting cells? Here, a model is presented in which the nonclassical MHC class II molecule HLA-DM plays a pivotal role as a chaperone, catalyst and editor during epitope selection.

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