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How does endothelial cell injury start? The role of endothelin in systemic sclerosis

✍ Scribed by David Abraham, Oliver Distler

Book ID
120706465
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
392 KB
Volume
9
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular