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The Role of Endothelial Cell Injury in Thrombotic Microangiopathy

โœ Scribed by Ryan J. Goldberg; Takahiko Nakagawa; Richard J. Johnson; Joshua M. Thurman

Book ID
114469981
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
451 KB
Volume
56
Category
Article
ISSN
0272-6386

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We have defined an in vitro model for the study of microvascular endothelial cell (EC) apoptosis mediated by plasma from patients with various forms of thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). This system reproduces a variety of histopathologic and ultrastructur